Case reports

← vista completa

Published on November 16, 2016 | http://doi.org/10.5867/medwave.2016.10.6609

Dermatomyositis as the first manifestation of small cell carcinoma: case report and literature review

Dermatomiositis como primera manifestación de un carcinoma de células pequeñas: caso clínico y revisión de la literatura

Herman Ahumada Piña , Luis Fuentes Cabrera, Rodrigo Selamé Glena, Daniel García Oneto, Andrea Jiménez Aguilar, Claudia Durán Herrera, Jorge Ávila Pérez, Maximiliano Cortés Latorre

Abstract

Dermatomyositis is an autoimmune inflammatory myopathy associated with dermatologic findings. Its association with neoplasms is widely reported and has been shown to be higher in lung cancer, particularly small-cell carcinoma, probably as it originates from neuroendocrine cell precursors, as well as breast and ovarian cancer. The low frequency of dermatomyositis makes it difficult to suspect the underlying lesions among the diagnostic possibilities of systemic diseases with cutaneous manifestations. Therefore, the high probability of a neoplasm should always be considered, with reports of up to 75% in the eastern population and about 40% in general. In this report, we present a rare case of dermatomyositis with lesions in a shawl-like distribution, as a symptomatic debut of a small cell lung carcinoma.

This article does not have an English version.

 

This work is licensed under a Creative Commons Attribution 4.0 International License. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.

Authors

Herman Ahumada Piña

Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Valparaíso, Chile

andita007@gmail.com

Hospital Eduardo Pereira, Calle Ibsen sin número esquina Noruega, Valparaíso, Chile

Luis Fuentes Cabrera

Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Valparaíso, Chile

Rodrigo Selamé Glena

Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Valparaíso, Chile

Daniel García Oneto

Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Valparaíso, Chile

Andrea Jiménez Aguilar

Claudia Durán Herrera

Jorge Ávila Pérez

Maximiliano Cortés Latorre

Figures

Article has no figures.

Forum

No messages

History

Citation Ahumada Piña H, Fuentes Cabrera L, Selamé Glena R, García Oneto D, Jiménez Aguilar A, Durán Herrera Cet al. Dermatomyositis as the first manifestation of small cell carcinoma: case report and literature review. Medwave 2016;16(10):e6609 doi: 10.5867/medwave.2016.10.6609

Submission date 18/08/2016

Acceptance date 20/10/2016

Publication date 16/11/2016

Metrics

Not available at the moment.

Notes

Keywords

dermatomyositis, paraneoplastic syndrome, small cell carcinoma

Origin and peer review

con revisión por dos pares revisores externos, a doble ciego

References

  1. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975 Feb 13;292(7):344-7. | PubMed
  2. Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975 Feb 20;292(8):403-7. | PubMed
  3. Paraschiv B, Diaconu CC, Toma CL, Bogdan MA. Paraneoplastic syndromes: the way to an early diagnosis of lung cancer. Pneumologia. 2015;64(2):14-9. | PubMed
  4. Casciola-Rosen L, Nagaraju K, Plotz P, Wang K, Levine S, Gabrielson E, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med. 2005 Feb 21;201(4):591-601. | PubMed
  5. Albert TJ, Bastawrous S, Raugi GJ, Hirschmann JV. A 62-year-old man with skin rash and an abnormal chest radiograph. Chest. 2015 Mar;147(3):e90-4. | CrossRef | PubMed
  6. Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010 Sep;85(9):838-54. | CrossRef | PubMed
  7. Sigurgeirsson B, Lindelöf B, Edhag O, Allander E. Risk of cancer in patients with dermatomyositis or polymyositis. A population-based study. N Engl J Med. 1992 Feb 6;326(6):363-7. | PubMed
  8. Stertz G. Polymiositis. BerlKlinWochenschr. 1916;53:489.
  9. Kankeleit H. Uber primairenicheitrigepolymiositis. Dtsch Arch Klin Med. 1916;120:335-39.
  10. Bernard P, Bonnetblanc JM. Dermatomyositis and malignancy. J Invest Dermatol. 1993 Jan;100(1):128S-132S. | PubMed
  11. Leow YH, Goh CL. Malignancy in adult dermatomyositis. Int J Dermatol. 1997 Dec;36(12):904-7. | PubMed
  12. Di Rollo D, Abeni D, Tracanna M, Capo A, Amerio P. Cancer risk in dermatomyositis: a systematic review of the literature. G Ital Dermatol Venereol. 2014 Oct;149(5):525-37. | PubMed
  13. Airio A, Pukkala E, Isomäki H. Elevated cancer incidence in patients with dermatomyositis: a population based study. J Rheumatol. 1995 Jul;22(7):1300-3. | PubMed
  14. Buchbinder R, Forbes A, Hall S, Dennett X, Giles G. Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study. Ann Intern Med. 2001 Jun 19;134(12):1087-95. | PubMed
  15. Chow WH, Gridley G, Mellemkjaer L, McLaughlin JK, Olsen JH, Fraumeni JF Jr. Cancer risk following polymyositis and dermatomyositis: a nationwide cohort study in Denmark. Cancer Causes Control. 1995 Jan;6(1):9-13. | PubMed
  16. Stockton D, Doherty VR, Brewster DH. Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: a Scottish population-based cohort study. Br J Cancer. 2001 Jul 6;85(1):41-5. | PubMed
  17. Zhang W, Jiang SP, Huang L. Dermatomyositis and malignancy: a retrospective study of 115 cases. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):77-80. | PubMed
  18. Dourmishev LA, Popov JM, Rusinova D. Paraneoplastic dermatomyositis associated with testicular cancer: a case report and literature review. Acta Dermatovenerol Alp Pannonica Adriat. 2010;19(1):39-43. | PubMed
  19. Fung WK, Chan HL, Lam WM. Amyopathic dermatomyositis in Hong Kong --association with nasopharyngeal carcinoma. Int J Dermatol. 1998 Sep;37(9):659-63. | PubMed
  20. Selvaag E, Thune P, Austad J. [Dermatomyositis and cancer. A retrospective study]. Tidsskr Nor Laegeforen. 1994 Aug 30;114(20):2378-80. | PubMed
  21. Wang J, Guo G, Chen G, Wu B, Lu L, Bao L. Meta-analysis of the association of dermatomyositis and polymyositis with cancer. Br J Dermatol. 2013 Oct;169(4):838-47. | CrossRef | PubMed
  22. Olazagasti JM, Baez PJ, Wetter DA, Ernste FC. Cancer risk in dermatomyositis: a meta-analysis of cohort studies. Am J Clin Dermatol. 2015 Apr;16(2):89-98. | CrossRef | PubMed
  23. Peng JC, Sheen TS, Hsu MM. Nasopharyngeal carcinoma with dermatomyositis. Analysis of 12 cases. Arch Otolaryngol Head Neck Surg. 1995 Nov;121(11):1298-301. | PubMed
  24. Wong KO. Dermatomyositis: a clinical investigation of twenty-three cases in Hong Kong. Br J Dermatol. 1969 Jul;81(7):544-7. | PubMed
  25. Chao G, Fang L, Lu C, Chen Z. Small cell lung cancer presenting as dermatomyositis: mistaken for single connective tissue disease. Rheumatol Int. 2012 Jun;32(6):1737-40. | CrossRef | PubMed
  26. Lee WY, Kastelik J, Campbell A, Avery G, McGivern D, Lind M. A case report of dermatomyositis associated with small cell lung cancer. Tumori. 2012 Nov;98(6):158e-61e. | CrossRef | PubMed
  27. Azuma K, Yamada H, Ohkubo M, Yamasaki Y, Yamasaki M, Mizushima M, et al. Incidence and predictive factors for malignancies in 136 Japanese patients with dermatomyositis, polymyositis and clinically amyopathic dermatomyositis. Mod Rheumatol. 2011 Apr;21(2):178-83. | CrossRef | PubMed
  28. Chen YJ, Wu CY, Shen JL. Predicting factors of interstitial lung disease in dermatomyositis and polymyositis. Acta Derm Venereol. 2007;87(1):33-8. Erratum in: Acta Derm Venereol. 2007;87(3):286. | PubMed
  29. Ponyi A, Constantin T, Garami M, András C, Tállai B, Váncsa A, et al. Cancer-associated myositis: clinical features and prognostic signs. Ann N Y Acad Sci. 2005 Jun;1051:64-71. | PubMed
  30. Al-Ballaa ST, Al-Dalaan AN, El-Ramahi KM, Al-Janadi MA, Al-Shaikh A, Bahabri S. Pattern of adult onset of polymyositis and dermatomyositis and association with malignancy. Ann Saudi Med. 1993 Nov;13(6):525-9. | PubMed
  31. András C, Ponyi A, Constantin T, Csiki Z, Szekanecz E, Szodoray P, et al. Dermatomyositis and polymyositis associated with malignancy: a 21-year retrospective study. J Rheumatol. 2008 Mar;35(3):438-44. | PubMed
  32. Sparsa A, Liozon E, Herrmann F, Ly K, Lebrun V, Soria P, et al. Routine vs extensive malignancy search for adult dermatomyositis and polymyositis: a study of 40 patients. Arch Dermatol. 2002 Jul;138(7):885-90. | PubMed
  33. Parodi A, Caproni M, Marzano AV, De Simone C, La Placa M, Quaglino P, et al. Dermatomyositis in 132 patients with different clinical subtypes: cutaneous signs, constitutional symptoms and circulating antibodies. Acta Derm Venereol. 2002;82(1):48-51. | PubMed
  34. Duncan AG, Richardson JB, Klein JB, Targoff IN, Woodcock TM, Callen JP. Clinical, serologic, and immunogenetic studies in patients with dermatomyositis. Acta Derm Venereol. 1991;71(4):312-6. | PubMed
  35. Trallero-Araguás E, Rodrigo-Pendás JÁ, Selva-O'Callaghan A, Martínez-Gómez X, Bosch X, Labrador-Horrillo M, et al. Usefulness of anti-p155 autoantibody for diagnosing cancer-associated dermatomyositis: a systematic review and meta-analysis. Arthritis Rheum. 2012 Feb;64(2):523-32. | CrossRef | PubMed
  36. Chinoy H, Fertig N, Oddis CV, Ollier WE, Cooper RG. The diagnostic utility of myositis autoantibody testing for predicting the risk of cancer-associated myositis. Ann Rheum Dis. 2007 Oct;66(10):1345-9. | PubMed
  37. Targoff IN. Myositis specific autoantibodies. Curr Rheumatol Rep. 2006 Jun;8(3):196-203. | PubMed
  38. Spiro SG, Gould MK, Colice GL; American College of Chest Physicians. Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest. 2007 Sep;132(3 Suppl):149S-160S. | PubMed
  39. Krathen MS, Fiorentino D, Werth VP. Dermatomyositis. Curr Dir Autoimmun. 2008;10:313-32. | CrossRef | PubMed
  40. Levine SM. Cancer and myositis: new insights into an old association. Curr Opin Rheumatol. 2006 Nov;18(6):620-4. | PubMed
  41. Soejima M, Kang EH, Gu X, Katsumata Y, Clemens PR, Ascherman DP. Role of innate immunity in a murine model of histidyl-transfer RNA synthetase (Jo-1)-mediated myositis. Arthritis Rheum. 2011 Feb;63(2):479-87. | CrossRef | PubMed
  42. Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, et al. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med. 2002 Sep 16;196(6):781-91. | PubMed
  43. Iorizzo LJ 3rd, Jorizzo JL. The treatment and prognosis of dermatomyositis: an updated review. J Am Acad Dermatol. 2008 Jul;59(1):99-112. | CrossRef | PubMed
  44. Yu KH, Wu YJ, Kuo CF, See LC, Shen YM, Chang HC, et al. Survival analysis of patients with dermatomyositis and polymyositis: analysis of 192 Chinese cases. Clin Rheumatol. 2011 Dec;30(12):1595-601. | CrossRef | PubMed
  45. Shen C, Che G. Dermatomyositis as an antecedent sign of lung cancer in an eldly patient: a case report. J Thorac Dis. 2014 Feb;6(2):E15-8. | CrossRef | PubMed