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Published on August 14, 2020 | http://doi.org/10.5867/medwave.2020.07.7996

Acute amiodarone pulmonary toxicity with low impregnation dose: case report

Toxicidad pulmonar aguda por amiodarona con dosis baja de impregnación: reporte de caso

Julio O Cabrera-Rego , José D Luzurriaga Navas, Alberto A Yanes Quintana

Abstract

Amiodarone, considered a potent antiarrhythmic, is known to cause pulmonary toxicity. Chronic interstitial pneumonitis is the most common presentation. However, acute pulmonary toxicity is rare and has a higher case fatality rate. We present a 61-year-old patient with persistent atrial fibrillation who, after a one-month treatment with oral amiodarone at a low dose impregnation of 400 mg/day, develops acute pulmonary toxicity, with radiographic and tomographic resolution after antiarrhythmic suspension and steroid treatment.

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Authors

Julio O Cabrera-Rego

Unidad de Cuidados Coronarios Intensivos, Hospital Manuel Fajardo, La Habana, Cuba

jocabrera@infomed.sld.cu.

https://orcid.org/0000-0001-9372-6203

José D Luzurriaga Navas

Departamento de Imagenología, Hospital Manuel Fajardo, La Habana, Cuba

https://orcid.org/0000-0002-0080-2738

Alberto A Yanes Quintana

Unidad de Cuidados Coronarios Intensivos, Hospital Manuel Fajardo, La Habana, Cuba

https://orcid.org/0000-0001-6576-0738

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History

Citation Cabrera-Rego JO, Luzurriaga Navas JD, Yanes Quintana AA. Acute amiodarone pulmonary toxicity with low impregnation dose: case report. Medwave 2020;20(07):e7996 doi: 10.5867/medwave.2020.07.7996

Submission date 17/01/2020

Acceptance date 25/07/2020

Publication date 14/08/2020

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Notes

Keywords

amiodarone, pulmonary fibrosis, acute pulmonary toxicity

Origin and peer review

Con revisión por pares externa, por tres árbitros a doble ciego

References

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