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Published on August 6, 2014 | http://doi.org/10.5867/medwave.2014.07.6004

Is antibiotic prophylaxis in acute pancreatitis beneficial?

¿Es beneficiosa la profilaxis antibiótica en la pancreatitis aguda?

Gabriel Rada , José Peña

Abstract

There is controversy about the effects of prophylactic antibiotics in acute pancreatitis. Searching in Epistemonikos database, which is maintained by screening 19 databases, we identified 15 systematic reviews including 19 randomised studies overall. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded that prophylactic antibiotics may reduce mortality and length of hospitalization in patients with acute pancreatitis, but the quality of the evidence is low. The probability that future evidence change what we know is high.

This work is licensed under a Creative Commons Attribution 4.0 International License. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.

Authors

Gabriel Rada

radagabriel@epistemonikos.org

Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago centro, Chile

José Peña

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History

Citation Rada G, Peña J. Is antibiotic prophylaxis in acute pancreatitis beneficial?. Medwave 2014;14(07):e6004 doi: 10.5867/medwave.2014.07.6004

Submission date 01/01/1970

Acceptance date 01/01/1970

Publication date 06/08/2014

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References

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