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Published on May 7, 2021 | http://doi.org/10.5867/medwave.2021.04.8168

Atypical antipsychotics for delirium in hospitalized patients

Antipsicóticos atípicos para el tratamiento de delirium en pacientes hospitalizados

Daniza Belén Bilicic Ubierna, Nicolás Cattarinich Schiffrin, Daniela Coronel Cárdenas , Rubén Soto Munizaga, José Miguel Bernucci Piedra

Abstract

Introduction For the pharmacotherapy of delirium in elderly adults who are hospitalized, atypical antipsychotics are used. Currently, there is insufficient evidence on the effectiveness of this treatment in low complexity units.

Methods We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE/PubMed, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis, and generated a summary of findings table using the GRADE approach.

Results and conclusions We identified 13 systematic reviews that included three randomized trials. We concluded that the use of atypical antipsychotics in hospitalized patients likely increases the risk of mortality compared to placebo and could decrease the response rate associated with reducing the risk of adverse effects. Furthermore, using atypical antipsychotics probably results in low or no difference in the severity of delirium.

This article does not have an English version available.

This work is licensed under a Creative Commons Attribution 4.0 International License. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.

Authors

Daniza Belén Bilicic Ubierna

Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile

https://orcid.org/0000-0002-1421-8989

Nicolás Cattarinich Schiffrin

Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile

https://orcid.org/0000-0001-7420-5429

Daniela Coronel Cárdenas

Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile

dcoronelc@uft.edu.

https://orcid.org/0000-0002-6533-3266

Rubén Soto Munizaga

Departamento de Medicina interna, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile

https://orcid.org/0000-0002-2121-1291

José Miguel Bernucci Piedra

Departamento de Medicina interna, Facultad de Medicina, Universidad Finis Terrae, Santiago, Chile

https://orcid.org/0000-0002-1048-6249

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History

Citation Bilicic Ubierna DB, Cattarinich Schiffrin N, Coronel Cárdenas D, Soto Munizaga R, Bernucci Piedra JM. Atypical antipsychotics for delirium in hospitalized patients. Medwave 2021;21(3):e8168 doi: 10.5867/medwave.2021.04.8168

Submission date 28/11/2020

Acceptance date 23/03/2021

Publication date 07/05/2021

Metrics

Not available at the moment.

Notes

Keywords

Delirium, Antipsychotics, Atypical antipsychotics, Hospitalized patients, Epistemonikos, GRADE

Origin and peer review

Con revisión por pares externa, por dos árbitros a doble ciego.

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