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Published on December 1, 2012 | http://doi.org/10.5867/medwave.2012.11.5559

Liver regeneration in nonalcoholic fatty liver disease

Regeneración hepática en enfermedad de hígado graso no-alcohólica

Aldo Lagomarsino

Abstract

Steatosis is the accumulation of fat in hepatocytes, which may be the result of liver regeneration or pathological processes such as alcoholic and nonalcoholic fatty liver disease. Despite its importance, in both cases the exact mechanism that prevails in fatty liver regeneration is poorly understood. Previous studies have shown that patients with fatty liver express dispar regeneration, possibly due to the accumulation of reactive oxygen species generated by inflammatory processes caused by activation of Kupffer cells. In this article we review several factors that affect liver regeneration, trying to understand the underlying mechanism of dispar regeneration in fatty liver as a consequence of nonalcoholic fatty liver disease.

This work is licensed under a Creative Commons Attribution 4.0 International License. Esta licencia permite el uso, distribución y reproducción del artículo en cualquier medio, siempre y cuando se otorgue el crédito correspondiente al autor del artículo y al medio en que se publica, en este caso, Medwave.

Authors

Aldo Lagomarsino

Universidad Diego Portales, Santiago, Chile

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History

Citation Lagomarsino A. Liver regeneration in nonalcoholic fatty liver disease. Medwave 2012;12(11):e5559 doi: 10.5867/medwave.2012.11.5559

Submission date 12/08/2012

Acceptance date 01/10/2012

Publication date 01/12/2012

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Keywords

fatty liver, liver regeneration

Origin and peer review

con revisión externa por 2 revisores, a doble ciego

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