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Efficiency and comparability of using new evidence platforms for updating recommendations: Experience with a type-2 diabetes guideline in Colombia

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Distribution of the references returned for each of the eight recommendations being updated using the five search approaches.
References included after using each search approachTotal EBR (% of each EBR within the update)
Diabetes recommendations under reviewABCDE
1 - Add DPP4-i to metformin if out of goals & there is no CVD1531419332 (39)
2 - Add SGLT2-i to metformin if out of goals & CVD is present2253611 (13)
3 - Add GLP-1 (as 3rd medication, 1 being metformin) if out of goals & BMI>306135414 (17)
4 - Use RAS inhibitors to prevent/reduce proteinuria355067 (9)
5 - Assess HbA1c goals e/3-6 months (<7% or <6.5%)012113 (4)
6 - Add insulin if HBA1C is >10% at diagnosis3603512 (15)
7 - Estimate annually GFR based on serum creatinine101001 (1)
8 - Use monofilament test to screen for neuropathy020002 (2)
All recommendations (% of each approach)30 (37)20 (24)30 (37)31 (38)25 (30)82 *(100)
Found exclusively with this search approach (% within each contribution)9 (30)5 (25)9 (30)12 (39)9 (36)

DPP4-i, Dipeptidyl peptidase-4 inhibitors. EBR, Evidence-based recommendation. GLP, Glucagon-like peptide. HbA1c, Glycated hemoglobin GFR: Glomerular filtration rate. RAS, Renin-angiotensin system. SGLT2-i, Sodium-glucose cotransporter-2. BMI, Body mass index.

*There were 71 single references identified, as one may inform more than evidence-based recommendation.

Source: Prepared by the authors of thsi study.