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Reporte de caso
Medwave 2015 Sep;15(8):e6270 doi: 10.5867/medwave.2015.08.6270
Enfermedad de Kikuchi–Fujimoto: presentación de un caso pediátrico
Kikuchi-Fujimoto disease: pediatric case report
Eduardo Ojeda Lewis, Héctor Vásquez Paz
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Palabras clave: kikuchi-fujimoto disease, histiocytic necrotizing lymphadenitis, fever of unknown origin

Abstract

The Kikuchi-Fujimoto disease is a rare disease that occurs mostly in young adults, although some cases have been reported in children. It is usually characterized by fever and cervical lymphadenopathy. The etiology of the disease remains unknown. Its course is usually benign and self-limited. It has special histopathological features that allow the differential diagnosis with other entities, which from a clinical point of view can be very complicated. We report a 9 years 11 months old girl with lymphadenopathy and fever with five months evolution, which is the longest evolution among the cases reviewed by the authors in world literature. Given that the presentation of this disease in children is very rare, we estimate that the knowledge of this disease is relevant and pediatricians must consider it in the differential diagnosis of fever of unknown origin in children.


  Error Content : No se econtro el path especificado
Error Content : No se econtro el path especificado
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The Kikuchi-Fujimoto disease is a rare disease that occurs mostly in young adults, although some cases have been reported in children. It is usually characterized by fever and cervical lymphadenopathy. The etiology of the disease remains unknown. Its course is usually benign and self-limited. It has special histopathological features that allow the differential diagnosis with other entities, which from a clinical point of view can be very complicated. We report a 9 years 11 months old girl with lymphadenopathy and fever with five months evolution, which is the longest evolution among the cases reviewed by the authors in world literature. Given that the presentation of this disease in children is very rare, we estimate that the knowledge of this disease is relevant and pediatricians must consider it in the differential diagnosis of fever of unknown origin in children.

Autores: Eduardo Ojeda Lewis[1], Héctor Vásquez Paz[1]

Filiación:
[1] Servicio de pediatría, Hospital Nacional Dos de Mayo de Lima, Ministerio de Salud, Lima, Perú

E-mail: eojedalewis@gmail.com

Correspondencia a:
[1] Hospital Hipólito Unanue
Calle Blondel s/n
Cercado de Tacna
Perú

Citación: Ojeda Lewis E, Vásquez Paz H. Kikuchi-Fujimoto disease: pediatric case report. Medwave 2015 Sep;15(8):e6270 doi: 10.5867/medwave.2015.08.6270

Fecha de envío: 15/7/2015

Fecha de aceptación: 7/9/2015

Fecha de publicación: 28/9/2015

Origen: no solicitado

Tipo de revisión: con revisión por tres pares revisores externos, a doble ciego

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  1. Lee KY, Yeon YH, Lee BC. Kikuchi-Fujimoto disease with prolonged fever in children. Pediatrics. 2004 Dec;114(6):e752-6. | PubMed |
  2. Cuervo JL, Dandin P, Castiglioni T, Ortega L, Amaral D, Faifman R. [Kikuchi-Fujimoto disease: case report]. Arch Argent Pediatr. 2008 Dec;106(6):535-8. | CrossRef | PubMed |
  3. Poulose V, Chiam P, Poh WT. Kikuchi's disease: a Singapore case series. Singapore Med J. 2005 May;46(5):229-32. | PubMed |
  4. Guerra Alfonso T, Fernández Aguila J, Cabrera Zamora M, Viera Yaniz J, Silva Aguilar R. Linfadenitis necrotizante histiocitaria o enfermedad de Kikuchi-Fujimoto. A propósito de 2 observaciones. Rev cubana med 2007;46(1). | Link |
  5. Sierra ML, Vegas E, Blanco-González JE, GonzálezA, Martínez P, Calero MA. Kikuchi's disease with multisystemic involvement and adverse reaction to drugs. Pediatrics. 1999 Aug;104(2):e24. | PubMed |
  6. Manzano Infante MJ, Camacho Lovillo MS, Obando Santaella I, Mateos Checa R, Rodríguez González M. [Kikuchi-Fujimoto disease as a cause of lymphadenopathy]. An Pediatr (Barc). 2007 Jul;67(1):83-5. | PubMed |
  7. Gonzalvez Piñera J, Ruiz Cano R, García Rodriguez MR, Fernandez Cordova MS, Crusat Braña S, Sango Lamban M. Linfadenitis histiocitaria necrotizante (enfermedad de Kikuchi-Fujimoto) en niña de 7 años. Cir Pediatr 2000;13:126-128. | Link |
  8. Richards MJ, Sexton DJ, Thorner AR. Kikuchi’s Disease. UpToDate version Desktop 17.1 January 2009. uptodate.com [on line] | Link |
  9. Goldblatt F, Andrews J, Russell A, Isenberg D. Association of Kikuchi-Fujimoto's disease with SLE. Rheumatology (Oxford). 2008 Apr;47(4):553-4. | CrossRef | PubMed |
  10. Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J Rare Dis. 2006 May 23;1:18. | PubMed |
  11. Wang TJ, Yang YH, Lin YT, Chiang BL. Kikuchi-Fujimoto disease in children: clinical features and disease course. J Microbiol Immunol Infect. 2004 Aug;37(4):219-24. | PubMed |
  12. Arias-Stella CJ, Navarro F, Abugattas J, Arias-Stella J. Linfadenitis histiocitaria necrotizante. Primeras observaciones sobre la enfermedad de Kikuchi-Fujimoto en el Perú. Patología. 1996;34(4):263-70.
  13. Chung JY, Kim SW, Han TH, Lim SJ. Detection of the Bartonella henselae gene sequence in lymph nodes of children with Kikuchi's disease. Pediatrics. 2005 Apr;115(4):1112. | PubMed |
  14. Unger PD, Rappaport KM, Strauchen JA. Necrotizing lymphadenitis (Kikuchi's disease). Report of four cases of an unusual pseudolymphomatous lesion and immunologic marker studies. Arch Pathol Lab Med. 1987 Nov;111(11):1031-4. | PubMed |
  15. Imamura M, Ueno H, Matsuura A, Kamiya H, Suzuki T, Kikuchi K, Onoe T. An ultrastructural study of subacute necrotizing lymphadenitis. Am J Pathol. 1982 Jun;107(3):292-9. | PubMed |
  16. Ramanan AV, Wynn RF, Kelsey A, Baildam EM. Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis--is there a link? Case report and literature review. Rheumatology (Oxford). 2003 Apr;42(4):596-8. | PubMed |
  17. Debley JS, Rozansky DJ, Miller ML, Katz BZ, Greene ME. Histiocytic necrotizing lymphadenitis with autoimmune phenomena and meningitis in a 14-year-old girl. Pediatrics. 1996 Jul;98(1):130-3. | PubMed |
  18. Sato Y, Kuno H, Oizumi K. Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with aseptic meningitis. J Neurol Sci. 1999 Mar 1;163(2):187-91. | PubMed |
  19. Kim YM, Lee YJ, Nam SO, Park SE, Kim JY, Lee EY. Hemophagocytic syndrome associated with Kikuchi's disease. J Korean Med Sci. 2003 Aug;18(4):592-4. | PubMed |
  20. O'Neill D, O'Grady J, Variend S. Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med. 1998 Jan-Feb;18(1):79-88. | PubMed |
  21. Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer. 1989 May 1;63(9):1856-62. | PubMed |
  22. Veiga-González M, Fresno-Forcelledo F, Pérez del Río MJ, Triviño-López A, Riera-Velazco JR, Herrero-Zapatero A. Linfadenitis necrotizante no granulocítica (enfermedad de Kikuchi). Análisis morfológico de tres casos con especial atención al diagnóstico diferencial. Patología. 1996;29:295-302.
  23. Hua F, Zhu L. Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review. BMC Infect Dis. 2010 Mar 11;10:64. | CrossRef | PubMed |
  24. Park HS, Sung MJ, Park SE, Lim YT. Kikuchi-Fujimoto disease of 16 children in a single center of Korea. Pediatr Allergy Immunol. 2007 Mar;18(2):174-8. | PubMed |
  25. Blewitt RW, Kumar SN, Abraham JS. Recurrence of Kikuchi's lymphadenitis after 12 years. J Clin Pathol. 2000 Feb;53(2):157-8. | PubMed |
Lee KY, Yeon YH, Lee BC. Kikuchi-Fujimoto disease with prolonged fever in children. Pediatrics. 2004 Dec;114(6):e752-6. | PubMed |

Cuervo JL, Dandin P, Castiglioni T, Ortega L, Amaral D, Faifman R. [Kikuchi-Fujimoto disease: case report]. Arch Argent Pediatr. 2008 Dec;106(6):535-8. | CrossRef | PubMed |

Poulose V, Chiam P, Poh WT. Kikuchi's disease: a Singapore case series. Singapore Med J. 2005 May;46(5):229-32. | PubMed |

Guerra Alfonso T, Fernández Aguila J, Cabrera Zamora M, Viera Yaniz J, Silva Aguilar R. Linfadenitis necrotizante histiocitaria o enfermedad de Kikuchi-Fujimoto. A propósito de 2 observaciones. Rev cubana med 2007;46(1). | Link |

Sierra ML, Vegas E, Blanco-González JE, GonzálezA, Martínez P, Calero MA. Kikuchi's disease with multisystemic involvement and adverse reaction to drugs. Pediatrics. 1999 Aug;104(2):e24. | PubMed |

Manzano Infante MJ, Camacho Lovillo MS, Obando Santaella I, Mateos Checa R, Rodríguez González M. [Kikuchi-Fujimoto disease as a cause of lymphadenopathy]. An Pediatr (Barc). 2007 Jul;67(1):83-5. | PubMed |

Gonzalvez Piñera J, Ruiz Cano R, García Rodriguez MR, Fernandez Cordova MS, Crusat Braña S, Sango Lamban M. Linfadenitis histiocitaria necrotizante (enfermedad de Kikuchi-Fujimoto) en niña de 7 años. Cir Pediatr 2000;13:126-128. | Link |

Richards MJ, Sexton DJ, Thorner AR. Kikuchi’s Disease. UpToDate version Desktop 17.1 January 2009. uptodate.com [on line] | Link |

Goldblatt F, Andrews J, Russell A, Isenberg D. Association of Kikuchi-Fujimoto's disease with SLE. Rheumatology (Oxford). 2008 Apr;47(4):553-4. | CrossRef | PubMed |

Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J Rare Dis. 2006 May 23;1:18. | PubMed |

Wang TJ, Yang YH, Lin YT, Chiang BL. Kikuchi-Fujimoto disease in children: clinical features and disease course. J Microbiol Immunol Infect. 2004 Aug;37(4):219-24. | PubMed |

Arias-Stella CJ, Navarro F, Abugattas J, Arias-Stella J. Linfadenitis histiocitaria necrotizante. Primeras observaciones sobre la enfermedad de Kikuchi-Fujimoto en el Perú. Patología. 1996;34(4):263-70.

Chung JY, Kim SW, Han TH, Lim SJ. Detection of the Bartonella henselae gene sequence in lymph nodes of children with Kikuchi's disease. Pediatrics. 2005 Apr;115(4):1112. | PubMed |

Unger PD, Rappaport KM, Strauchen JA. Necrotizing lymphadenitis (Kikuchi's disease). Report of four cases of an unusual pseudolymphomatous lesion and immunologic marker studies. Arch Pathol Lab Med. 1987 Nov;111(11):1031-4. | PubMed |

Imamura M, Ueno H, Matsuura A, Kamiya H, Suzuki T, Kikuchi K, Onoe T. An ultrastructural study of subacute necrotizing lymphadenitis. Am J Pathol. 1982 Jun;107(3):292-9. | PubMed |

Ramanan AV, Wynn RF, Kelsey A, Baildam EM. Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis--is there a link? Case report and literature review. Rheumatology (Oxford). 2003 Apr;42(4):596-8. | PubMed |

Debley JS, Rozansky DJ, Miller ML, Katz BZ, Greene ME. Histiocytic necrotizing lymphadenitis with autoimmune phenomena and meningitis in a 14-year-old girl. Pediatrics. 1996 Jul;98(1):130-3. | PubMed |

Sato Y, Kuno H, Oizumi K. Histiocytic necrotizing lymphadenitis (Kikuchi's disease) with aseptic meningitis. J Neurol Sci. 1999 Mar 1;163(2):187-91. | PubMed |

Kim YM, Lee YJ, Nam SO, Park SE, Kim JY, Lee EY. Hemophagocytic syndrome associated with Kikuchi's disease. J Korean Med Sci. 2003 Aug;18(4):592-4. | PubMed |

O'Neill D, O'Grady J, Variend S. Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med. 1998 Jan-Feb;18(1):79-88. | PubMed |

Chan JK, Wong KC, Ng CS. A fatal case of multicentric Kikuchi's histiocytic necrotizing lymphadenitis. Cancer. 1989 May 1;63(9):1856-62. | PubMed |

Veiga-González M, Fresno-Forcelledo F, Pérez del Río MJ, Triviño-López A, Riera-Velazco JR, Herrero-Zapatero A. Linfadenitis necrotizante no granulocítica (enfermedad de Kikuchi). Análisis morfológico de tres casos con especial atención al diagnóstico diferencial. Patología. 1996;29:295-302.

Hua F, Zhu L. Kikuchi Fujimoto disease associated with cryptogenic organizing pneumonia: case report and literature review. BMC Infect Dis. 2010 Mar 11;10:64. | CrossRef | PubMed |

Park HS, Sung MJ, Park SE, Lim YT. Kikuchi-Fujimoto disease of 16 children in a single center of Korea. Pediatr Allergy Immunol. 2007 Mar;18(2):174-8. | PubMed |

Blewitt RW, Kumar SN, Abraham JS. Recurrence of Kikuchi's lymphadenitis after 12 years. J Clin Pathol. 2000 Feb;53(2):157-8. | PubMed |