Reporte de caso

Multicentric reticulohistiocytosis revealing a ductal breast cancer in situ: A case report with dermoscopic and histopathological findings

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Histopathology of skin lesion.

A. Image at low magnification corresponding to the superficial nodular and perifollicular infiltrate (H-E, original magnification 40x).

B. Cellular detail of the infiltrate, with histiocytic cells and multinucleated giant cells, with granular and eosinophilic cytoplasm, intermixed with lymphocytes, neutrophils, and plasma cells (H-E, original magnification 400x).

C. Immunohistochemical study showed that the histiocytic cells are positive for CD68. The rest of the immunohistochemical study was negative for CD1a, S100 protein, and CD34.

Source: Images obtained by the authors of this study.