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Dabrafenib más trametinib versus nivolumab para el tratamiento del melanoma avanzado

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About the certainty of the evidence (GRADE)*
About the certainty of the evidence (GRADE)*
⊕⊕⊕⊕High: This research provides a very good indication of the likely effect. The likelihood that the effect will be substantially different† is low.⊕⊕⊕◯Moderate: This research provides a good indication of the likely effect. The likelihood that the effect will be substantially different† is moderate⊕⊕◯◯Low: This research provides some indication of the likely effect. However, the likelihood that it will be substantially different† is high.⊕◯◯◯Very low: This research does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different† is very high.
*This concept is also called ‘quality of the evidence’ or ‘confidence in effect estimates’.† Substantially different: a large enough difference that it might affect a decision.