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Publicado el 24 de septiembre de 2014 | http://doi.org/10.5867/medwave.2014.08.6019

¿Es efectivo el ácido ursodeoxicólico en cirrosis biliar primaria?

Is ursodeoxycholic acid effective in primary biliary cirrhosis?

Gabriel Rada , Macarena Mac-Namara

Abstract

Ursodeoxycholic acid is considered as first line treatment in patients with primary biliary cirrhosis. Its mechanism of action in this disease is unknown and there is controversy about its clinical impact. Searching in Epistemonikos database, which is maintained by screening 19 databases, we identified four systematic reviews including 16 studies. We combined the evidence using tables with summary of findings following the GRADE approach and concluded ursodeoxycholic acid may not have any effect on pruritus, and there is uncertainty about its effect on mortality, need for liver transplantation or on any other important outcome for the patient.

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Autores

Gabriel Rada

radagabriel@epistemonikos.org

Macarena Mac-Namara

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Citación Rada G, Mac-Namara M. Is ursodeoxycholic acid effective in primary biliary cirrhosis?. Medwave 2014;14(08):e6019 doi: 10.5867/medwave.2014.08.6019

Envío 01/01/1970

Aceptación 01/01/1970

Publicación 24/09/2014

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Referencias

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