VIII Congreso Internacional de Investigación REDU
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Publicado el 25 de abril de 2022 | http://doi.org/10.5867/Medwave.2022.S1.CI24
Diseño de Nanopartículas Funcionales de Fluoruro de Calcio para Bioimagen
Design of Functional Calcium Fluoride Nanoparticles for Bioimaging
Kevin O. Pila-Varela , Cristhian Marcelo Chingo Aimacaña, Dilan Andrés Quinchiguango Pérez, Carlos Reinoso, Frank Alexis, Si Amar Dahoumane
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Palabras clave
CaF2 NPs, Synthesis, Colloidal Stability, Microscopy-Based Nanoparticle Characterization, X-Ray-Related Characterization, Biomedical Properties, Bioimaging
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Introducción
Calcium fluoride in its elemental formula is considered widely valuable for designing new technologies and applications in current science, such as metal alloying, the improvement of optical deposition, and the manufacture of products for the pharmaceutical sector. Generally, CaF2, in specific compositions, makes it possible to: improve optical quality by reducing light scattering, promoting remineralization in teeth as an effective anticaries agent, and even improving the ability as a contrast agent for bioimaging applications with high standards of success in the biomedical sector. If we consider CaF2 at the nanoscale, research and application fields are opened and intended to be explored initially in this work.
Objetivos
The efficient production of CaF2 nanoparticles (NPs) with interesting physical and chemical properties to later be used as a starting point in designing functional platforms in Bioimaging techniques such as ultrasound and X-ray activated tumor sonodynamic therapy.
Método
The synthesized nanoparticles were characterized by (SEM) to evaluate their morphology; Energy-dispersive X-ray spectroscopy (EDX) to evaluate its elemental composition, and Transmission electron microscopy (TEM) to evaluate colloidal suspension and its particle size and particle size distribution. Then, NPs were characterized by X-ray diffraction (XRD) to evaluate their crystalline phases and crystallite size and X-ray photoelectron spectroscopy (XPS) to evaluate their topographic surface at atomic percent ratio. Finally, a controlled sonication method will attempt the acquisition of stable aqueous suspensions and colloids of these NPs.
Principales Resultados
CaF2 NPs are efficiently synthesized, considering the basis of their composition to obtain a pure final product. Then, on the one hand, they are studied in depth using characterization techniques related to X-rays by X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). These provide information to identify the phases present in the polycrystalline structure and the chemical surface atomic percent ratio of the CaF2 particles confirming its elemental purity and crystallinity index of 86%. On the other hand, Scanning Electron Microscopy (SEM) allows the study of the surface's structure and morphology in conjunction with Energy Dispersion X-ray Spectroscopy (EDX) provides a complete mapping of the sample through the analysis of nearby surface elements to estimate the elemental composition being 1: 2 for CaF2. Finally, by obtaining stable aqueous suspensions of CaF2, Transmission Electron Microscopy (TEM) benefited the investigation of structural and size characterization, providing a more complex understanding of the stability and uniformity of the physical structures of CaF2 NPs obtaining an average diameter of dispersed particles of 36-56 nm.
Conclusiones
CaF2 NPs were efficiently synthesized of CaF2 NPs, considering their formulation composition produce a pure final product. They are studied in depth using microscopy-based and X-ray-related nanoparticle characterization techniques. In the same way, discovering these current data can be used to solve current problems as an efficient and stable means to create a new contrast medium for improved imaging modalities based on highly functionalizable, biocompatible, and biodegradable nanoparticles.
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