Notas metodológicas

Approaching the body of evidence: Key concepts of Overviews

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Representation of overlapping primary studies within an overview.

RCT: Randomized Clinical Trial. SR: Systematic Review.
Green circle: patients in whom treatment was beneficial.
Red circle: patients in whom treatment was not beneficial.
It could be erroneously concluded that drug A is superior to drug B because RCT 3 is overrepresented as it is included in several SR, thus overestimating its real effect.
Source: Prepared by the authors.