Revisión clínica

New perspectives on chagasic cardiomyopathy: A narrative review of genetics, magnetic resonance imaging and therapeutic alternatives

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Treatment according to phase (acute or chronic).
Acute phase
DrugDose according to weight
≤40kg>40kg
1° option: Benznidazol7.5 to 10 mg/kg/day (oral)5 to 7 mg/kg/day (oral)
In both cases, the dose should be divided into 2 to 3 daily doses for 60 days. Maximum dose: 300 mg/day
2° option: Nifurtimox10 to 15mg/kg/day (oral)8 to 10 mg/kg/day (oral)
In both cases, they should be divided into 2 to 3 daily doses for 60 days
Recent chronic phase
Benznidazol7.5mg/kg/day (oral)5mg/kg/day (oral)
In both cases, they should be divided into 2 to 3 daily doses for 60 days

≤,less than or equal to. >, greater than. kg, kilograms. mg/kg/d, milligrams per kilogram per day. mg/d, milligrams per day.

Any recent chronic infection (including in children 12 years of age or younger) and any chronically diagnosed infection requires a comprehensive general evaluation of the patient and a formal referral from the treating physician.

Source: Prepared by the authors based on Marin-Neto JA et al. [17] and PAHO [26].