Revisión clínica
← vista completaPublicado el 1 de marzo de 2011 | http://doi.org/10.5867/medwave.2011.03.4949
Actualización en el manejo de hepatitis B
An update in the management of hepatitis B
Abstract
The first description of the so-called surface antigen (HBsAg) appears in 1965. It was discovered in Australia in an aboriginal 45 years ago and from then on continuing basic and clinical research has been conducted. By now it is know that the disease is of viral origin and has a roster of genotypes.
Currently 9 viral genotypes have been described, from A to I. The latest one was discovered in 2010. The differences lie in the genome since there are more than 3000 nucleotides available. The different genotypes occur whenever there is a more than 5-7% discrepancy. The true relevance of the genotypes is unknown; however, genotype C leads to a more serious condition, with greater progression risk towards cirrhosis and hepatocarcinoma than genotypes A and B that respond better to antiviral interferon therapy, which in the future could impact treatment decisions.
