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Published on January 12, 2017 | http://doi.org/10.5867/medwave.2017.01.6839

Pathophysiology of diabetic nephropathy: a literature review

Fisiopatología de la nefropatía diabética: una revisión de la literatura

Carlos Eduardo Meza Letelier , Camilo Alfredo San Martín Ojeda, José Javier Ruiz Provoste, Cristobal Jesus Frugone Zaror

Abstract

Chronic kidney disease is a common complication of diabetes. Its importance lies in its high prevalence and future projection. It is associated with high health costs and global cardiovascular deterioration as well. The development of this disease pathophysiology is being studied and it is known that a series of complex molecular pathways determining a microvascular disease are involved. This review addresses the known pathways in the development of diabetic nephropathy aiming to improve the understanding of potential therapeutic targets that could be developed in the future.

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Authors

Carlos Eduardo Meza Letelier

Facultad de Medicina, Universidad Católica del Maule, Talca, Región del Maule, Chile

c.meza.letelier@gmail.com

Calle Cuatro y Medio Norte B 3415, Talca, Región del Maule, Chile

Camilo Alfredo San Martín Ojeda

Facultad de Medicina, Universidad Católica del Maule, Talca, Región del Maule, Chile

José Javier Ruiz Provoste

Facultad de Medicina, Universidad Católica del Maule, Talca, Región del Maule, Chile

Cristobal Jesus Frugone Zaror

Facultad de Medicina, Universidad Católica del Maule, Talca, Región del Maule, Chile

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History

Citation Meza Letelier CE, San Martín Ojeda CA, Ruiz Provoste JJ, Frugone Zaror CJ. Pathophysiology of diabetic nephropathy: a literature review. Medwave 2017;17(01):e6839 doi: 10.5867/medwave.2017.01.6839

Submission date 28/10/2016

Acceptance date 12/12/2016

Publication date 12/01/2017

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Notes

Keywords

diabetic nephropathy, microvascular complications, chronic renal disease physiopathology

Origin and peer review

con revisión por tres pares revisores externos, a doble ciego

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