Estudios originales
Published on 30 de abril de 2024 | http://doi.org/10.5867/medwave.2024.03.2783
Asociación de los genotipos de IGF-1 e IGF-2 con la fuerza muscular respiratoria en individuos con EPOC: estudio transversal
| Age (years) | 67.3 ± 7.6 |
| Male, n (%) | 33 (54%) |
| BMI (Kg/m2) | 26.9 ± 5.4 |
| FVC % predicted | 83.4 ± 20.9 |
| FEV1 % predicted | 49.2 ± 15.2 |
| GOLD % (I, II, III, IV) | 1/27/27/6 |
| MIP (cmH2O) | 75.9 ± 26.9 |
| MEP (cmH2O) | 107.9 ± 38.0 |
| SNP IGF-1 a | |
| AA, n (%) | 3 (5%) |
| AG, n (%) | 24 (43%) |
| GG, n (%) | 29 (52%) |
| SNP IGF-2 b | |
| CC, n (%) | 12 (23%) |
| CG, n (%) | 18 (34%) |
| GG, n (%) | 23 (43%) |
| Vitamin D (ng/ml) | 26.9 ± 11.9 |
| SOD (U/mgHb) | 45.3 ± 13.9 |
| CAT (U/mgHb) | 49.8 ± 11.2 |
| TNF-α (pg/dl) | 0.19 ± 1.2 |
| IL-6 (pg/dl) | 2.6 ± 2.7 |
BMI, Body mass index. CAT, Catalase. FEV1, Forced expiratory volume in one second. FVC, Forced vital capacity. GOLD, Global Initiative for Chronic Obstructive Lung Disease. IGF-1, Insulin growth factor-1. IGF-2, Insulin growth factor-2. IL-6, Interleukin six. MEP, Maximal expiratory pressure. MIP, Maximal inspiratory pressure. SNP, Single nucleotide polymorphism. SOD, superoxide dismutase. TNF-α, Tumor necrosis factor-alpha.
a analysis run with 56 patients and b analysis run with 53 patients.
Source: Prepared by the authors based on the study’s results.