Estudios originales
Published on 30 de abril de 2024 | http://doi.org/10.5867/medwave.2024.03.2783
Asociación de los genotipos de IGF-1 e IGF-2 con la fuerza muscular respiratoria en individuos con EPOC: estudio transversal
Back to article
Multivariate general linear model (GLM) analysis with the respiratory muscle strength as dependent variables and the SNPs of IGF-1 and IGF-2, age and sex as exploratory variables.
| Respiratory muscle strength (MIP and MEP) | SNP IGF-2 | 3.5 | 2 | 0.13 | 0.01 | |
| SNP IGF-1 | 3.0 | 2 | 0.23 | 0.024 | ||
| Age | 2.8 | 1 | 0.07 | 0.72 | ||
| Sex | 18.4 | 1 | 0.21 | <0.001 | ||
| MIP | SNP IGF-2 | 5.6 | 2 | 0.27 | 0.007 | |
| SNP IGF-1 | 5.4 | 2 | 0.20 | 0.008 | ||
| Vitamin D | 1.86 | 1 | 0.08 | 0.18 | ||
| SOD | 3,47 | 1 | 0.13 | 0.068 | ||
| CAT | 0.71 | 1 | 0.09 | 0.403 | ||
| TNF-α | 0.26 | 1 | 0.01 | 0.611 | ||
| IL-6 | 0.15 | 1 | 0.04 | 0.702 | ||
| Age | 5.2 | 1 | 0.16 | 0.028 | ||
| Sex | 24.5 | 1 | 0.45 | <0.001 | ||
| MEP | SNP IGF-2 | 4.7 | 2 | 0.21 | 0.014 | |
| SNP IGF-1 | 2.2 | 2 | 0.13 | 0.125 | ||
| Vitamin D | 1.17 | 1 | 0.05 | 0.286 | ||
| SOD | 2.85 | 1 | 0.13 | 0.097 | ||
| CAT | 1.78 | 1 | 0.06 | 0.188 | ||
| TNF-α | 2.03 | 1 | 0.02 | 0.161 | ||
| IL-6 | 2.47 | 1 | 0.06 | 0.124 | ||
| Age | 2.1 | 1 | 0.09 | 0.097 | ||
| Sex | 24.8 | 1 | 0.48 | <0.001 |
CAT, Catalase. IGF-1, Insulin growth factor-1. IGF-2, Insulin growth factor-2. IL-6, Interleukin six. MEP, Maximal expiratory pressure. MIP, Maximal inspiratory pressure. SOD, superoxide dismutase. TNF-α, Tumor necrosis factor-alpha. Statistical difference
Source: Prepared by the authors based on the study´s results.