Estudios originales
Published on 21 de julio de 2025 | http://doi.org/10.5867/medwave.2025.06.3002
Thrombotic thrombocytopenic purpura: Description and analysis of 23 cases treated in Chile between 2017 and 2022
Back to article
Demographic, clinical, symptom and laboratory history.
| Women (%) | 16 (70%) |
| Age (median in years and IQR) | 62 (38 to 77) |
| Presence of comorbidities (%) | 19 (83%) |
| Charlson comorbidity index (points and IQR) | 4 (1.5 to 6.0) |
| Hematological neoplasms | 4 (17%) |
| Hematopoietic precursor transplants | 0 |
| Chronic renal disease | 6 (26%) |
| Hemodialysis | 2 (8.7%) |
| Anemia | 5 (22%) |
| Cirrhosis | 3 (13%) |
| Rheumatologic diseases | 4 (17%) |
| Systemic lupus erythematosus | 2 (8.7%) |
| Antiphospholipid syndrome | 1 (4.3%) |
| Neurological conditions | 6 (26%) |
| STROKE/TIA | 5 (22%) |
| Epilepsy | 1 (4.3%) |
| Poliomyelitis sequelae | 1 (4.3%) |
| Arterial hypertension | 10 (44%) |
| Diabetes mellitus | 7 (30%) |
| Pulmonary diseases | 4 (17%) |
| Heart failure | 3 (13%) |
| Active infections1 | 6 (26%) |
| Constitutional | 19 (86%) |
| Gastrointestinal | 12 (52%) |
| Hemorrhagic | 10 (44%) |
| Neurological | 8 (35%) |
| Glasgow Coma Scale < 9 | 4 (17%) |
| Seizures | 2 (8.7%) |
| Platelets | 18 000/mcL (9500 to 43 000) |
| LDH | 617 U/L(353 to 1129) |
| Hemoglobin | 7.9 g/dL (6.1 to 8.7) |
| Creatinine | 1.71 mg/dL(0.96 to 2.6) |
IQR, intercuartile range. LDH, lactate dehydrogenase. TIA, transient ischemic attack.
1 Active infections included periodontal sepsis, intra-abdominal sepsis, SARS-CoV-2 pneumonia and BK virus-associated nephropathy.
Source: Prepared by the authors based on the results of the study.