Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women

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Published on 8 de mayo de 2025 | http://doi.org/10.5867/medwave.2025.04.3010

Effects of novel multicomponent exercise programs on brain-derived neurotrophic factor levels and physical fitness in older women

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Levels of BDNF and measurements of physical fitness pre- and post-intervention of each group with intention to treat analyses.

Variables		FT (n=24)	PM(n=25)	CG(n=41)	Difference between groups (post-post comparison)
		Mean ±SD	Mean ±SD	Mean ±SD	Group Comparison	Cohen’s d (CI 95%)	p-value	p-value group* time
BDNF (pg/mL)
Pre		1285.59 ± 523.71	1291.10 ± 597.15	1642.49 ± 931.36	FT versusPM	-0.157(-0.718 to 0.404)	1.000	<0.001
Post		1720.97 ± 647.32	1611.74 ± 738.23	1350.02 ± 529.99	FT versusCG	-0.644(-1.16 to 0.129)	0.064
Pre-post comparison	Cohen’s d (CI 95%)	0.884(0.232 to 1.418)	0.777 (0.391 to 1.541)	-0.292(-0.759 to 0.123)	PM versusCG	-0.425(-0.927 to 0.078)	0.380
Pre-post comparison	p-value	<0.001*	0.001*	0.025*
6MWT (m)
Pre		487.88 ± 66.71	467.11 ± 57.74	475.67 ± 55.03	FT versusPM	-1.122(-1.724 to -0.519	<0.001	0.007
Post		529.55 ± 49.89	463.14 ± 66.94	474.23 ± 52.31	FT versusCG	-1.075(-1.612 to -0.539)	<0.001
Pre-post comparison	Cohen’s d (CI 95%)	0.491(-0.139 to 1.01)	-0.045(-0.593 to 0.539)	-0.018(-0.451 to 0.426)	PM versusCG	0.19(-0.308 to 0.689)	1.000
Pre-post comparison	p-value	0.001*	0.760	0.856
SPPB (score)
Pre		10.91 ± 0.91	10.19 ± 1.73	10.52 ± 1.58	FT versusPM	-0.689(-1.265 to -0.112)	0.050	0.998
Post		11.62 ± 0.64	10.91 ± 1.30	11.21 ± 0.90	FT versusCG	-0.503(-1.014 to 0.008)	0.135
Pre-post comparison	Cohen’s d (CI 95%)	0.58(-0.081 to 1.074)	0.333(-0.258 to 0.858)	0.463(0.113 − 1.002)	PM versusCG	0.281(-0.219 to 0.781)	0.883
Pre-post comparison	p-value	0.001*	0.07	0.001*
AGI (s)
Pre		24.95 ± 3.20	27.47 ± 4.64	26.05 ± 3.48	FT versusPM	0.352(-0.213 to 0.916)	0.543	0.412
Post		24.78 ± 2.88	26.10 ± 4.43	25.15 ± 4.31	FT versusCG	0.096(-0.408 to 0.6)	1.000
Pre-post comparison	Cohen’s d (CI 95%)	-0.081(-0.694 to 0.438)	-0.382(-1.075 to 0.067)	-0.31(-0.763 to 0.118)	PM versusCG	-0.218(-0.717 to 0.281)	1.000
Pre-post comparison	p-value	0.720	0.132	0.150
HGT (kg)
Pre		26.59 ± 4.26	24.77 ± 3.49	26.05 ± 3.76	FT versus PM	-0.217(-0.779 to 0.345)	1.000	0.393
Post		26.70 ± 4.25	25.79 ± 4.13	26.17 ± 4.85	FT versus CG	-0.114(-0.618 to 0.390)	1.000
Pre-post comparison	Cohen’s d (CI 95%)	0.064(-0.408 to 0.724)	0.451(-0.058 − 1.18)	0.042(-0.391 to 0.485)	PM versus CG	0.083(-0.415 to 0.580)	1.000
Pre-post comparison	p-value	0.806	0.074	0.832

Brain-derived Neurotrophic Factor, BDNF. Functional Training, FT. Handgrip Test, HGT. Pilates Method, PM. Short Physical Performance Battery. SPPB. Six-minute walk test, 6MWT. Agility Test, AGI. Control Group, CG.

Data are presented as mean ± standard deviation.

* p ≤ 0.05. ITT analysis performed with FT (n=24). PT (n=25) and CG (n=40).

Source: Prepared by the authors od this study.