Estudios originales
Published on 26 de junio de 2025 | http://doi.org/10.5867/medwave.2025.05.3037
Descriptive analysis of immunological abnormalities in recurrent reproductive failure and therapeutical outcomes
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Alterations found in the patient population.
| Expansion of cytotoxic NK cells in peripheral blood (> 13% of lymphocytes) | 120 (49.5%) |
| Positive antiphospholipid antibodies | 92 (38.5%) |
| Positive antinuclear antibodies (IFA) | 48 (21.9%) |
| Positive anti-thyroid antibodies | 38 (16.8%) |
| Complement impairment (C3/C4) | 23 (10.7%) / 69 (32.2%) |
| Maternal-fetal KIR-HLA-C mismatch | 38 (39.1%) |
| Monocytosis (>10%) | 22 (10.5%) |
| Positive anti-transglutaminase IgA antibodies | 5 (2.1%) |
| Genetic susceptibility CD | 134 (78.6%) |
| D-dimer > 400 ng/ml baseline | 39 (25.8%) |
| Fibrinogen >450 mg/dl baseline | 51 (27.1%) |
| Homocysteine >12 umol/L | 11 (6.2%) |
| HOMA > 3 | 24 (26.3%) |
| TSH > 2.5 uIU/ml | 37 (18.0%) |
| Vitamin D < 30 ng/ml | 110 (53.1%) |
CD, celiac disease. HLA-C, human leucocyte antigen C. HOMA, homeostatic model assessment. IFA, indirect immunofluorescence. IgA, immunoglobulin A. KIR, killer immunoglobulin-like receptors (killer immunoglobulin-like receptors).NK, Natural Killers. TSH, thyrotropin, thyroid-stimulating hormone.
Data expressed in absolute numbers (%).
Source: Prepared by the authors based on the results of the study.