Estudios originales
Published on 19 de agosto de 2026 | http://doi.org/10.5867/medwave.2026.07.3216
Efficacy and safety of goserelin vs. leuprolide in premenopausal breast cancer patients receiving adjuvant endocrine therapy: A retrospective cohort study
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Statistical table of biochemical indicators for study subjects.
| Estrogen levels (n) | 51 (56.67%) | 56 (57.73%) | 0.634 | −1.06 (−15.25 to 13.13) |
| Sex hormone levels (18.2-135.5 nmol/L) | 81 (90.00%) | 84 (86.60%) | 3.40% (−5.79% to 12.59%) | |
| Estradiol levels (≤30 pg/mL) | 80 (88.89%) | 90 (92.78%) | 0.354 | −3.89% (−12.18% to 4.40%) |
| Testosterone levels (0.1-0.75 ng/mL) | 84 (93.33%) | 93 (95.88%) | −2.55% (−9.04% to 3.94%) | |
| Luteinizing hormone levels (2.12-10.89 mIU/mL) | 65 (72.22%) | 66 (68.04%) | 4.18% (−8.93% to 17.29%) | |
| Follicle-stimulating hormone levels (3.85-8.78 mIU/mL) | 65 (72.22%) | 67 (69.07%) | 3.15% (−9.90% to 16.20%) | |
| Prolactin levels (3.34-26.72 ng/mL) | 86 (95.56%) | 95 (97.94%) | −2.38% (−7.50% to 2.74%) | |
| CEA Assay (n) | 84 (93.33%) | 90 (92.78%) | 0.549 | 0.55% (−6.74% to 7.84%) |
| CA-15-3 (0-25 U/mL） | 89 (98.89%) | 96 (98.97%) | −0.08% (−3.04% to 2.88%) | |
| CEA (0-5 ng/mL） | 90 (100%) | 97 (100%) | ||
| Liver function (n) | 63 (70.00%) | 84 (86.60%) | 0.012 | −16.60% (−28.24% to −4.96%) |
| ALT (7-50 U/L) | 77 (85.56%) | 94 (96.91%) | −11.35% (−19.39% to −3.31%) | |
| AST (13-40 U/L) | 76 (84.44%) | 90 (92.78%) | −8.34% (−17.43% to 0.75%) | |
| GT (7-60 U/L) | 76 (84.44%) | 89 (91.75%) | −7.31% (−16.58% to 1.96%) | |
| Total Bilirubin (≤20 umol/L) | 82 (91.11%) | 97 (100%) | −8.89% (−14.77% to −3.01%) | |
| Thyroid Function (n) | 80 (88.89%) | 74 (76.29%) | 0.018 | 12.60% (1.94% to 23.26%) |
| TSH (0.3-5.5 ulU/mL) | 84 (93.33%) | 81 (83.51%) | 9.82% (0.82% to 18.82%) | |
| FT3 (3.1-6.8 pmol/L) | 88 (97.78%) | 96 (98.97%) | −1.19% (−4.84% to 2.46%) | |
| FT4 (12-22 pmol/L） | 81 (90.00%) | 90 (92.78%) | −2.78% (−10.84% to 5.28%) |
ALT Alanine aminotransferase, AST Aminotransferase, GT Glutamyltransferase, CEA Carcinoembryonic Antigen, AFP Alpha-fetoprotein, TSH Thyroid-stimulating hormone, FT3 Free Triiodothyronine, FT4 Free Thyroxine.
Source: Prepared by the authors of this study.