Symic smallpox: From warning to practice - Medwave

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Published on 15 de octubre de 2024 | http://doi.org/10.5867/medwave.2024.09.3008

Symic smallpox: From warning to practice

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Smallpox vaccines used as Mpox vaccines [9].

Mpox vaccine	Licensed	Replication	Pre-exposure indications	Post-exposure indications
ACAM2000	USA	Competent replication	High-risk occupational groups; not recommended for the general population.	Close contact with someone or something that has Mpox.
JYNNEOS	USA	Modified poor replication	High-risk occupational groups; preferred for those with contraindication. Same as above: high-risk occupational groups preferred for those with contraindications; pregnant women	Same as above: high-risk occupational groups preferred for those with contraindications; pregnant women
LC16m8	Japan	Attenuated, minimally replication-competent	High-risk occupational groups: preferred for those with contraindications; not recommended for the general population	Same as above: high-risk occupational groups preferred for those with contraindications; pregnant women not inoculated with JYNNEOS; licensed in Japan for use in children

Source: Yukian et al. 2022 [4].