Notas metodológicas
Published on 15 de mayo de 2024 | http://doi.org/10.5867/medwave.2024.04.2790
Key factors in the choice of appropriate outcomes for clinical trials
Back to article
Examples of dissociation between surrogate and clinically relevant outcomes.
| Cerivastatin | Dislipidemia | Improvement in lipid profile. | Increased mortality due to rhabdomyolysis. |
| Rosiglitazone | Diabetes mellitus | Decrease in HbA1c. | Increased cardiovascular mortality. |
| Torcetrapib | Dislipidemia | Increase in plasma levels of HDL cholesterol. | Increased all-cause mortality. |
| Fluoride | Osteoporosis | Increase in bone mineral densitometry. | Increased risk of fractures. |
HDL, high-density lipoprotein; HbA1c, glycosylated hemoglobin A1c.
Source: Adapted from [15][18][19][20].