Evaluation of new antibiotic drugs in severe community-acquired pneumonia.
Droga
Clase
Espectro
Característica especial
Ceftaroline
Fifth-generation cephalosporin
Gram-positive, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.Enterobacteriaceae (non-β-lactamase-, carbapenemase-, or AmpC-producing broad-spectrum β-lactamase).
MRSA, multidrug-resistant Streptococcus pneumoniae; Staphylococcus resistant to glycopeptides, linezolid, and daptomycin. Ceftaroline is not active against non-fermenting gram-negative bacilli.
Ceftobiprole
Fifth-generation cephalosporin
Gram-negative bacteria, including Pseudomonas aeruginosa and Enterobacteriaceae (ESBL negative), with the advantage of covering gram-positive bacteria (MRSA, penicillin-resistant Streptococcus pneumoniae, ampicillin-sensitive E. faecalis).The activity on other important pathogens (Acinetobacter spp., Stenotrophomonas maltophilia andBacteroides spp.) is limited
Omadacycline
Tetracycline
Broad-spectrum activity against gram-positive and gram-negative aerobes and anaerobes, in addition to atypical bacteria
Methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus pneumoniae, and vancomycin-resistant Enterococcus.
Lefamunin
Pleuromutilin
Gram-positive and atypical organisms related to bacterial CAP (e.g., Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydophila pneumoniae)
Staphylococcus aureus (MRSA, vancomycin-intermediate and heterogeneous strains) and vancomycin-resistant Enterococcus.
Solithromycin
Fluroketolide (macrolide)
Gram-positive, gram-negative, and atypical pathogens causing pneumonia
Streptococcus pneumoniae (especially strains resistant to microbes, fluoroquinolones, and penicillins), Haemophilus influenzae, and atypical pathogens causing pneumonia
