Artículo de revisión
Published on 24 de abril de 2023 | http://doi.org/10.5867/medwave.2023.03.2619
Effect of epigenetics on rheumatoid arthritis
Potential mechanism of differentially methylated genes in rheumatoid arthritis (RA) regulated by various epigenetic drugs. multiple epigenetic drugs.
DNA methylation is exerted by DNA methyltransferases. DNA methyltransferases are influenced by epigenetic drugs that inhibit or activate them, leading to gene expression modulation. The down-arrow indicates hypomethylated genes (STA3, interleukin-6, CXCL12, DUSP22, STAT4, IRF5, IFIH1) and the up-arrow indicates hypermethylated genes (DR3, interleukin-10, DUSP22).
Figure adapted by the authors from the review results by Ciechomska, M et al.